منابع مشابه
HIV-1 Reservoirs and Latency: Critical Barriers and Clues for HIV / AIDS Cure
Human immunodeficiency virus type 1 (HIV-1) infection is still a formidable threat to public health in spite of remarkable therapeutic advances (Adoga et al., 2009; Goselle, 2011). Highly active antiretroviral therapy (HAART) is effective against HIV/AIDS but it is not curative, and hence does not lead to the eradication of HIV-1 infection. Patients on HAART usually have their HIV RNA levels su...
متن کاملMarkov process models of the dynamics of HIV reservoirs.
While latently infected CD4+ T cells are extremely sparse, they are a reality that prevents HIV from being cured, and their dynamics are largely unknown. We begin with a two-state Markov process that models the outcomes of regular but infrequent blood tests for latently infected cells in an HIV positive patient under drug therapy. We then model the hidden dynamics of a latently infected CD4+ T ...
متن کاملHIV Persistence and Viral Reservoirs
Although antiretroviral therapy (ART) can effectively inhibit replication of human immunodeficiency virus type 1 (HIV-1), the virus is able to persist in cellular and anatomical viral reservoirs. Latently infected resting memory CD4 T-cells are an important cellular reservoir, and the central nervous system (CNS) an important anatomical reservoir for HIV-1 infection. The overall aim of this the...
متن کاملA Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs
Latently infected cells form the major obstacle to HIV eradication. Studies of HIV latency have been generally hindered by the lack of a robust and rapidly deployable cell model that involves primary human CD4 T lymphocytes. Latently infected cell lines have proven useful, but it is unclear how closely these proliferating cells recapitulate the conditions of viral latency in non-dividing CD4 T ...
متن کاملElimination of HIV-1-Infected Primary T Cell Reservoirs in an In Vitro Model of Latency
Establishment of long-lived cellular reservoirs of HIV-1 represents a major therapeutic challenge to virus eradication. In this study, we utilized a human primary cell model of HIV-1 latency to evaluate the requirements for efficient virus reactivation from, and the selective elimination of, latently infected human T cells. Ectopic expression of BCL2 supported the replication and spread of R5-t...
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ژورنال
عنوان ژورنال: Virology
سال: 2011
ISSN: 0042-6822
DOI: 10.1016/j.virol.2010.12.041